TEAM

Flow-type continuous chemical synthesis has various advantages such as drastic reduction of waste, improved safety, and cost reduction compared to conventional batch-type synthesis methods. Flow Chemistry Team is focusing on the development of catalysts and reactions for the continuous flow synthesis. We are also working with researchers and engineers inside and outside AIST to develop the entire process, including separation and purification.

Team Leader, Dr. Nagatoshi Koumura (Ph. D.)

研究テーマ

  • Continuous precision production process development
  • Artificial intelligence related technology development
  • Catalyst-related technology development

Development of catalysts for continuous flow synthesis

active for a long time and prevent the catalyst from dissolving into the reaction medium (leaching). We are conducting research aimed at developing highly active and highly selective catalysts with such characteristics.

Development of new methodology for the catalyst design with artificial intelligence

Catalysts used in flow synthesis must have different characteristics from conventionalbatch synthesis methods. In order to pack the catalyst in the reaction column and use it continuously for a long time, it is necessary to ke active for a long time and prevent the catalyst from dissolving into the reaction medium (leaching). We are conducting research aimed at developing highly active and highly selective catalysts with such characteristics.

Three-Component Catalyst System

In addition to the above-mentioned continuous flow technology, we are also studying on the synthesis of silicon and bismuth compounds and their utilization as catalysts and reagents based on their unique properties.

メンバー

  • Team Leader

    Nagatoshi Koumura

  • Chief Senior Researcher

    Shigeru Shimada

  • Senior Researcher

    Shun-ya Onozawa

  • Senior Researcher

    Akira Yada

  • Researcher

    Koichiro Masuda

  • Researcher

    Yasukazu Kobayashi

  • AIST Postdoctoral Researcher

    Md. Rashed Nurnobi

  • AIST Postdoctoral Researcher

    Teruhiko Tanaka

  • Technical Staff

    Kaori Nagaoka

  • Technical Staff

    Junko Takaishi

  • Temporary Staff

    Yukiko Okamoto

  • Tenporary Technical staff

    Ikuo Saitou

  • Tenporary Technical staff

    Bannai Hideaki

  • Tenporary Technical staff

    Yukiko Okamoto

  • Tenporary Technical staff

    Chie Negoro

  • Tenporary Technical staff

    Megumi Akiyama

  • visiting Researcher

    CHEN Wenlong

  • visiting Researcher

    Tetsuo Nakajo

  • visiting Researcher

    Tomomi Horikoshi

*Please add “@aist.go.jp” after each local part.

研究成果

(8) Masuda, K.; Wang, Y.; Onozawa, S.; Shimada, S.; Koumura, N.; Sato, K.; Kobayashi, S. “Robust Organic Photosensitizers Immobilized on a Vinylimidazolium Functionalized Support for Singlet Oxygen Generation under Continuous-Flow Conditions”, Synlett 2020, 31, 497-501.

(7) Ichitsuka, T.; Suzuki, N.; Sairenji, M.; Koumura, N.; Onozawa, S.; Sato, K.; Kobayashi, S. “Readily Available Immobilized Pd Catalysts for Suzuki‐Miyaura Coupling under Continuous‐flow Conditions”, ChemCatChem 2019, 11, 2427-2431.

(6) Aoyama, T.; Tashiro, K.; Hayakawa, M.; Shimada, S.; Ouchi, A. “Novel synthesis of 1,4-thiazin-2-one O-(tert-butyl) oximes and benzo[b][1,4]thiazin-2-one O-(tert-butyl) oximes in the presence of K2CO3/SiO2”, Tetrahedron Lett. 2019, 60, 1493-1497.

(5) Yada, A.; Nagata, K.; Ando, Y.; Matsumura, T.; Ichinoseki, S.; Sato, K. “Machine Learning Approach for Prediction of Reaction Yield with Simulated Catalyst Parameters”, Chem. Lett. 2018, 47, 284-287.

(4) Han, L.-B.; Mirzaei, F.; Shimada, S.; “Regio- and stereoselective addition of trans-Pt(TeAr)(SiMe3)(PEt3)2 to terminal alkynes leading to cis-[(Z)-β-trimethylsilylalkenyl]platinum(II) complexes”, Heteroatom Chem. 2018, 29, e21463.

(3) Aoyama, T.; Tashiro, K.; Hayakawa, M.; Shimada, S.; Ouchi, A. “A simple and efficient method for the synthesis of 5,6-dihydropyrazin-2(1H)-one O-(tert-butyl)oximes, quinoxalin-2(1H)-one O-(tert-butyl)oximes and its derivatives”, Tetrahedron Lett. 2018, 59, 4116-4119.

(2) Srinivas, V.; Nakajima, Y.; Sato, K.; Shimada, S. “Iridium-Catalyzed Hydrosilylation of Sulfur-containing Olefins”, Org. Lett. 2018, 20, 12-15.

(1) Masuda, K.; Ichitsuka, T.; Koumura, N.; Sato, K.; Kobayashi, S. “Flow Fine Synthesis with Heterogeneous Catalysts”, Tetrahedron 2018, 74, 1705-1730.