Flow Chemistry Team

Flow-type continuous chemical synthesis has various advantages such as drastic reduction of waste, improved safety, and cost reduction compared to conventional batch-type synthesis methods. Flow Chemistry Team is focusing on the development of catalysts and reactions for the continuous flow synthesis. We are also working with researchers and engineers inside and outside AIST to develop the entire process, including separation and purification.

Team Leader, Dr. Nagatoshi Koumura (Ph. D.)

Theme

  • Continuous precision production process development
  • Artificial intelligence related technology development
  • Catalyst-related technology development

Development of catalysts for continuous flow synthesis

active for a long time and prevent the catalyst from dissolving into the reaction medium (leaching). We are conducting research aimed at developing highly active and highly selective catalysts with such characteristics.

Development of new methodology for the catalyst design with artificial intelligence

Catalysts used in flow synthesis must have different characteristics from conventionalbatch synthesis methods. In order to pack the catalyst in the reaction column and use it continuously for a long time, it is necessary to ke active for a long time and prevent the catalyst from dissolving into the reaction medium (leaching). We are conducting research aimed at developing highly active and highly selective catalysts with such characteristics.

Three-Component Catalyst System

In addition to the above-mentioned continuous flow technology, we are also studying on the synthesis of silicon and bismuth compounds and their utilization as catalysts and reagents based on their unique properties.

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Members

Position Name Email(*)
Team Leader Nagatoshi Koumura n-koumura
Chief Senior Researcher Shigeru Shimada s-shimada
Senior Researcher Shun-ya Onozawa s-onozawa
Senior Researcher Akira Yada a-yada
Researcher Koichiro Masuda koichiro-masuda
Researcher Yasukazu Kobayashi yasu-kobayashi
AIST Postdoctoral Researcher Delgado Delgado Alonso Jorge
AIST Postdoctoral Researcher Md. Rashed Nurnobi
AIST Postdoctoral Researcher Naoto Eguchi
AIST Postdoctoral Researcher Teruhiko Tanaka
Technical Staff Shingo Komatsuzaki
Technical Staff Kaori Nagaoka
Technical Staff Junko Takaishi
Technical Staff Yukiko Okamoto
Tenporary Technical staff Ikuo Saitou
Tenporary Technical staff Bannai Hideaki
Tenporary Technical staff Yukiko Okamoto
Tenporary Technical staff Chie Negoro
Tenporary Technical staff Megumi Akiyama
visiting Researcher CHEN Wenlong
visiting Researcher Tetsuo Nakajo
Assistant Tomomi Horikoshi
  • ※後ろに「@aist.go.jp」を付けて下さい。

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Results

(8) Masuda, K.; Wang, Y.; Onozawa, S.; Shimada, S.; Koumura, N.; Sato, K.; Kobayashi, S. “Robust Organic Photosensitizers Immobilized on a Vinylimidazolium Functionalized Support for Singlet Oxygen Generation under Continuous-Flow Conditions”, Synlett 2020, 31, 497-501.

(7) Ichitsuka, T.; Suzuki, N.; Sairenji, M.; Koumura, N.; Onozawa, S.; Sato, K.; Kobayashi, S. “Readily Available Immobilized Pd Catalysts for Suzuki‐Miyaura Coupling under Continuous‐flow Conditions”, ChemCatChem 2019, 11, 2427-2431.

(6) Aoyama, T.; Tashiro, K.; Hayakawa, M.; Shimada, S.; Ouchi, A. “Novel synthesis of 1,4-thiazin-2-one O-(tert-butyl) oximes and benzo[b][1,4]thiazin-2-one O-(tert-butyl) oximes in the presence of K2CO3/SiO2”, Tetrahedron Lett. 2019, 60, 1493-1497.

(5) Yada, A.; Nagata, K.; Ando, Y.; Matsumura, T.; Ichinoseki, S.; Sato, K. “Machine Learning Approach for Prediction of Reaction Yield with Simulated Catalyst Parameters”, Chem. Lett. 2018, 47, 284-287.

(4) Han, L.-B.; Mirzaei, F.; Shimada, S.; “Regio- and stereoselective addition of trans-Pt(TeAr)(SiMe3)(PEt3)2 to terminal alkynes leading to cis-[(Z)-β-trimethylsilylalkenyl]platinum(II) complexes”, Heteroatom Chem. 2018, 29, e21463.

(3) Aoyama, T.; Tashiro, K.; Hayakawa, M.; Shimada, S.; Ouchi, A. “A simple and efficient method for the synthesis of 5,6-dihydropyrazin-2(1H)-one O-(tert-butyl)oximes, quinoxalin-2(1H)-one O-(tert-butyl)oximes and its derivatives”, Tetrahedron Lett. 2018, 59, 4116-4119.

(2) Srinivas, V.; Nakajima, Y.; Sato, K.; Shimada, S. “Iridium-Catalyzed Hydrosilylation of Sulfur-containing Olefins”, Org. Lett. 2018, 20, 12-15.

(1) Masuda, K.; Ichitsuka, T.; Koumura, N.; Sato, K.; Kobayashi, S. “Flow Fine Synthesis with Heterogeneous Catalysts”, Tetrahedron 2018, 74, 1705-1730.

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